Autoimmunity to Uroplakin II Causes Cystitis in Mice: A Novel Model of Interstitial Cystitis
نویسندگان
چکیده
منابع مشابه
Uroplakin Peptide-Specific Autoimmunity Initiates Interstitial Cystitis/Painful Bladder Syndrome in Mice
The pathophysiology of interstitial cystitis/painful bladder syndrome (IC/PBS) is enigmatic. Autoimmunity and impaired urothelium might lead the underlying pathology. A major shortcoming in IC/PBS research has been the lack of an appropriate animal model. In this study, we show that the bladder specific uroplakin 3A-derived immunogenic peptide UPK3A 65-84, which contains the binding motif for I...
متن کاملThe role of TSG-6 and uroplakin III in bladder pain syndrome/ interstitial cystitis in rats and humans
Objective(s):We investigated the relationship between the expression of tumor necrosis factor-inducible gene 6 (TSG-6) with inflammation and integrity of the bladder epithelium in the bladder tissues of patients with bladder pain syndrome/interstitial cystitis (BPS/IC) and the mechanism of action using a rat model of BPS/IC. Materials and Methods: Expression of TSG-6 and uroplakin III was det...
متن کاملInterstitial cystitis.
Deborah L. Myers, MD Interstitial cystitis (IC) is a chronic condition of urinary urgency, frequency, and suprapubic pain in the absence of bacteruria. It is part of the painful bladder syndrome whose known causes are tuberculosis, stones, malignancy, previous chemotherapy of the bladder, and pelvic radiation. Interstitial cystitis is a diagnosis of exclusion when no known cause of painful bla...
متن کاملInterstitial cystitis.
Interstitial cystitis, described for many years, remains a mystery for several reasons. Although the clinical and therapeutic understanding of this disease have improved, the histological features are non-specific and the pathogenesis is still unclear. The aim of this article is to briefly review the current state of knowledge and to remind the reader that this disease must not be underestimate...
متن کاملInterstitial Cystitis
Keri Marshall, MS, ND – 1996 Master of Science Social and Preventive Medicine, State University of New York at Buffalo; 2001 graduate, National College of Naturopathic Medicine. Private practice, Sandpoint, Idaho Correspondence address: 515 Pine St., Suite H, Sandpoint, ID 83864 Email: [email protected] Abstract Interstitial cystitis (IC) is a chronic pain syndrome that affects close to a millio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Urology
سال: 2012
ISSN: 0302-2838
DOI: 10.1016/j.eururo.2011.06.028